PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .

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A total of 1.

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Your email has been sent! We then would wait up to min and if still occluded we then try a 2nd psckage of Alteplase of an equal amount and begin the process again. Studies have only evaluated up to two 2-mg doses. General Certain causes of catheter dysfunction should be considered before treatment with Cathflo Activase e.

Would you like to mark this message as the new best answer? Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide: Central Venous Catheter Instillation Administration Alteplase is instilled into the occluded lumen of a central venous catheter.

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The interaction of Cathflo Activase with other drugs has not been formally studied. Prothrombin Complex Concentrate, Human: Various dosages and administration cathlfo have been studied.

In another controlled study, patients who did not receive concomitant IV nitroglycerin reperfused faster, more often, and had fewer reocclusions. Powered by Higher Logic. Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required.


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In vitro data support that cryopreserved alteplase solutions maintain bioactivity in propylene syringes for 6 months and in glass vials for 2 weeks. Promptly evaluate any signs or symptoms of blood loss in patients on concomitant therapy.

Consider the potential risk of reembolization due to lysis of the underlying deep vein thrombi in patients with inserh embolism. The reconstituted product is a colorless to pale yellow transparent solution. In exploratory, multivariate analyses, age more than 77 years was among baseline characteristics associated with an increased risk for intracranial hemorrhage.

Dosage & Administration – Cathflo® Activase® (alteplase)

Systemic alteplase can cause significant, sometimes fatal, internal or external bleeding, especially at arterial and venous puncture sites. We have a few patients who are unsert producers, so form the sheath. Genentech will not contact the individuals you share content with.

In clinical trials, several episodes of bleeding were reported. You cathfpo also report side effects to Genentech at View videos and instructions for the recommended dosing and administration of Cathflo. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.

The treatment of patients with minor neurological deficit or with rapidly improving symptoms is not recommended as the safety and efficacy vathflo these patients has not been evaluated.


Patients should be instructed to monitor for signs and symptoms of bleeding while taking an SNRI with medications which impair platelet function and to promptly report any bleeding events to the practitioner. Moderate Increased effects from concomitant anticoagulant drugs including increased bruising or blood in the stool have been reported in patients taking methylsulfonylmethane, Packahe.

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Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term studies in animals have not been performed to evaluate the carcinogenic potential or the effect on fertility. Following dilution, the solution is stable for up to 8 hours at room temperature. Choline Salicylate; Magnesium Salicylate: If catheter function is not restored at minutes after 1 dose of Cathflo, a second dose may be instilled see Instructions for Administration.

The reconstituted preparation results in a colorless to pale yellow transparent solution at a pH of approximately 7. I must ask the question as I am hearing lots of rumble from my in-patient colleagues about For subcutaneous ports, 0. Monitor clinical and laboratory response closely during concurrent use.

If you have time, don’t bother checking after the first 30 minuets. The reconstituted product contains no antibacterial preservatives and should be reconstituted immediately before use.