MK using large scale airlift bioreactors (ALBs), a scale-up study HIDRODINÁMICA DE UN BIORREACTOR AIRLIFT TRIFÁSICO. oil as the sole carbon source in an air-lift bioreactor and a stirred-tank reactor biorreactores/ fermentadores; neomycine; huile de soja; neomycin; aceite de. Itaconic acid production in an air-lift bioreactor using a modified draft tube []. Okabe aspergillus terreus; itaconic acid; biorreactores; acido itaconico; acide.

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Oxygen transfer is usually helped by agitation, which is also needed to mix nutrients and to keep the fermentation homogeneous. In an aerobic process, optimal oxygen transfer is sometimes the rate limiting step.

Itaconic acid production in an air-lift bioreactor using a modified draft tube

A bioprocess is composed mainly of three stages — upstream processing, biotreactores, and downstream processing — to convert raw material to finished product. Please help by editing the article to make improvements to the overall structure. Thus,Equations 15 and 16 are the basic equations which are used for the modelling of any bioreactor.

Often content unacceptable to Wikipedia may not be acceptable on Wikiversity either; facilitate the copying of this article by listing it on Wikiversity: In practice, bioreactors are often pressurized; this increases the solubility of oxygen in water. NASA’s tissue bioreactor can grow heart tissue, skeletal tissue, ligaments, cancer tissue for study, and other types of tissue.

A photobioreactor PBR is a bioreactor which incorporates some type of light source that may be natural sunlight or artificial illumination.


This page was last edited on 30 Decemberat Wikimedia Commons has media related to Bioreactors. Articles needing additional references from October All articles needing additional references Wikipedia articles needing reorganization from April Articles with multiple maintenance issues Wikipedia articles with style issues from July All articles with style airift Commons category link is on Wikidata Wikipedia articles with NDL identifiers.

It may also refer to a device or system designed to grow cells or tissues in the context of cell culture. In bioreactors in which the goal is to grow cells or tissues for experimental or therapeutic purposes, the design is significantly different from industrial bioreactors.


To avoid it, the bioreactor must be easily cleaned. Jacket — The jacket provides the annular area for circulation of constant temperature of water which keeps the temperature of the bioreactor at a constant value.

The downstream process is mainly consists of physical separation operations which includes, solid liquid separation, adsorptionliquid-liquid extractiondistillationdrying etc. In some of these systems, a chemically inert medium with very high surface area airkift provided as a substrate for the growth of biological film.

For more information on artificial tissue culture, see tissue engineering. July Learn how and when to remove this template message. These models are useful for planning efficient process control strategies and predicting the future plant performance.

Particularly exothermic fermentations may require the use of external heat exchangers. Unsourced material may be challenged and removed. The pH of the medium is measured and adjusted with small amounts of acid or base, depending upon the fermentation.

For aerobic and some anaerobic fermentations, reactant gases especially oxygen must be added to the fermentation. Many cells and tissues, especially mammalian ones, must have a surface or other structural support in order to grow, and agitated environments are often destructive to these cell types and tissues. Bioreactor design is a relatively complex engineering task, which is studied in the discipline of biochemical engineering. In this instance, the biosludge itself is the primary host for the bacteria.

From Wikipedia, the free encyclopedia. Oxygen is poorly soluble in water—even less in warm fermentation broths—and is relatively scarce in air This section’s tone or style may not reflect the encyclopedic tone used on Wikipedia. Applications of biochemical engineering cover major fields of civilization such as agriculture, food and healthcare, resource recovery and fine chemicals.

In these biorreachores, the liquid’s Biochemical Oxygen Demand BOD is reduced sufficiently to render the contaminated biorreactoers fit for reuse. Enzyme Microb Tech, This article may be in need of reorganization to comply with Wikipedia’s layout guidelines.


Bioreactor – Wikipedia

Heat transfer is an important part of bioreactor design; small vessels can be cooled with a cooling jacket, but larger vessels may require coils or an external heat exchanger. Suspension bioreactors can use a wider variety of organisms, since special attachment surfaces are not needed, and can operate at much larger scale than immobilized cultures. Zirlift emergence of Biochemical engineering is of recent origin.

On the basis of mode of operationa bioreactor may be classified as batchfed batch or continuous e. Higher organisms, being auxotrophicalso require highly specialized growth media. Where r 1 is the rate of cell generation. If the page can be re-written into an encyclopedic article, please do so and remove this message.

The biosolids can be collected for further processing, or dried and used as fertilizer. Photobioreactors are used to grow small phototrophic organisms such as cyanobacteriaalgaeor moss plants.

In other systems biorreactoores supply oxygen to the sewage and biota to create activated sludge in which the biological component is freely mixed in the liquor in “flocs”. NASA has developed a new type of bioreactor that artificially grows tissue in cell cultures.

Sparger — In aerobic cultivation process, the purpose of the biorreactroes is to supply adequate oxygen to the growing cells. Views Read Edit View history. This page is a candidate to be copied to Wikiversity using the Import process. However, in a continuously airlivt process the organisms will be removed from the reactor with the effluent. Virtually any translucent container could be called a PBR, however the term is more commonly used to define a closed system, as opposed to an open tank or pond.