A.I.VOGEL PREPARATYKA ORGANICZNA PDF

A.I.VOGEL PREPARATYKA ORGANICZNA PDF

A. I. Vogel, Preparatyka organiczna (WNT Warszawa,), p. Zielińska J., Makowski M., Maj K., Liwo A., Chmurzyński L.() Anal. A.I. Vogel. Preparatyka Organiczna, WNT, Warszawa (), p. F.V. Lovecchio, E.S. Gore, D.H. Bush. J. Am. Chem. Soc., 96 (), p. Soc. (), p. A.I. Vogel. Preparatyka Organiczna W.N.T. Warszawa ( ), p. C.G. Hatchard, C.A. Parker. Proc. Roy. Soc., A (), p.

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Stinson, Chemical and Engineering News, Compound was prepared using an alternative step B relative to the preparation of compoundbut the general procedure described above for compound was otherwise generally followed for each of steps A, C, and D.

Uh 13b dayz download Press the Download Now button to download and install Uh 1y Dayz Preparatyka organiczna vogel download. Intermediate compound 11 ofganiczna prepared using the method described above with respect to intermediate compound 10, but 2-aminobromopurine was used in place of 6-bromopurine.

The process of claim 18 further comprising. Final Office Action mailed on Feb. Compound 30 was prepared using the general procedure described above with respect to compound 14, but 3-benzyloxytert-butoxycarbonylaminopropionic acid 2,5-dioxo-pyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, the alternate procedure TFA deprotection was used in step C, and 4-chloro-7H-pyrrolo[2,3-d]pyrimidine was substituted for 6-bromopurine in step D.

In the general structure N R x R y R zmono-substituted a.u.vogel have orgqniczna of the three substituents on nitrogen R xR y and R z.i.vogel as hydrogen; di-substituted amines have 1 of the three substituents on nitrogen R xR y and R z as hydrogen; and tri-substituted amines have none of the three substituents on nitrogen R xR y and R z as hydrogen. Ofganiczna Office Action mailed on Feb. In some embodiments, step a is performed at a temperature between 0 and 45 degrees Celsius, between 15 and 40 degrees Celsius, or between 20 and 30 degrees Celsius.

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Furthermore, the processes disclosed herein may be suitable for various purposes, such as one or more of laboratory, industrial, commercial, non-commercial, manufacturing, non-manufacturing, regulatory, non-regulatory, medical, non-medical, pharmaceutical, and experimental uses.

In some embodiments, step d includes combining the compound of formula 5 or a salt thereof and a compound a.i.vpgel formula 6 with a base.

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The process of claim 19wherein the compound of formula 19 or a salt thereof is crystallized from one or more solvents selected from the group consisting of isopropanol, n-propanol, ethanol, methanol, and water. Compounds and pharmaceutical compositions suitable for use in the present invention include those wherein the active ingredient is administered in an effective amount to achieve its intended purpose. Rowlinson-Busza et al, ” Targeted delivery of biologic and other antineoplastic agents.

Principles and Practice of Oncology 4th ed. In further embodiments, R 3 is an amino protective group and R 4 is a purinyl group. The pharmaceutical composition can be provided as a salt of the active agent. Compound 53 was prepared using the general procedure described above with respect to compound 14, but anthranilic acid was substituted for 2-aminomethylbenzoic acid in step A, 2-tert-butoxycarbonylamino-propionic acid 2,5-dioxopyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, and the alternate procedure TFA deprotection was used in step C.

Notice of Allowance mailed on Sep. Compound 23 was prepared using the general procedure described above with respect to compound 14, but 2-aminobromopurine was substituted for 6-bromopurine in step D.

The obtained 2-[1- 2-amino-9H-purinylamino tert-butoxy-ethyl]methylphenyl-3H-quinazolinone was then dissolved in trifluoroacetic acid and allowed to stir at ambient temperature for 5 hours.

In some embodiments, the base is pyridine, 4-dimethylaminopyridine, triethylamine, isopropylethylamine, imidazole, DABCO, DBU, 2,6-lutidine, N,N-diisopropylethylamine, or a mixture thereof.

Pharmaceutical compositions comprising the agent in dosages suitable for oral administration prepartyka be formulated using pharmaceutically acceptable carriers well known in the art. Such compounds may exhibit increased resistance to metabolism and may thus be useful for increasing the half-life of a compound of any formula described herein, for instance formula II or formula III, when administered to a mammal.

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The reaction mixture was stirred for 18 h at ambient temperature, evaporated to dryness, and the resulting residue was dissolved in organicznx 20 mL. Final Office Action from U. In particular, the methods a.i.vohel the invention can be practiced using compounds having the general structural formula I:. Liposomes containing the active agent also can be employed for parenteral administration. Compound was prepared by reacting compound prepared following the procedure for the preparation of compound 14 step D using three equivalents of diisopropylethylamine instead of one.

Preparatyka organiczna vogel pdf download

After three hours, the reaction was allowed to cool and the resulting suspension was filtered. Compound was obtained by first reaction compound in accordance with the procedure for compound In one embodiment, the compound of formula 5 is the salt of the compound of formula The inflammatory functions of neutrophils can be distinguished from the bacterial killing functions exhibited by these cells, e.

In a further embodiment, at least 2 molar equivalents of the DPP diphenylphosphite with respect to the compound of formula 16 is combined with the compound of formula 16 and a compound of formula 10a.

In some embodiments, compositions may comprise a multi-kilogram amount of a compound of a formula disclosed herein or salt thereof.

Compound 64 is shown below. Response to Election of Species Requirement from U.